Protasomes ? another possible marker for prostate cancer ...


A story in Science Daily, based on new article in the Proceedings of the National Academy of Sciences (PNAS) , has suggested that blood levels of ?protasomes? may be a more accurate marker for prostate cancer risk that PSA levels in blood. So what is a ?protasome??

Some 30 years ago a young Swedish researcher called Gunnar Ronquist was able to demonstrate that prostate cells make large amounts of a very small membrane-coated particle that is commonly found in semen. He named these particles ?prostasomes.? (Note: It is important to distinguish carefully between ?protasomes? and the molecules known as ?proteasomes,? which have a very different type of function.)

It is still not entirely clear to the current writer exactly what the normal role of protasomes is in male fertility and sexual transmission of genetic information. However, according to the paper by Tavoosida et al.?in PNAS, in men with prostate cancer, rather than accumulating in semen, prostasomes are (for some reason) ?pumped out into the surrounding cancer tissue.? As a consequence, prostasomes can be expected to occur at elevated levels in the serum samples of these patients.

Tavoosida et al. have (so far) been able to do three things.

In the first place they have been able to develop a test that can identify protasomes in serum (a test that did not exist until recently). They have then been able to apply this test to show that levels of prostasomes in serum levels of prostate cancer patients seem to correlate more closely with the severity of the disease than do PSA levels.

Specifically, the authors have shown that the average (median) levels of prostasomes in blood plasma of patients with prostate cancer were 2.5 to 7.0 times higher than the protasome levels in the plasma of control samples (in two independent studies). Furthermore, they have also been able to use the protasome levels to distinguish between patients with post-prostatectomy Gleason scores? of 7 and 8/9 and patients with Gleason score ? 6. In other words, they seem to have found a blood-based test that may be able to act as a proxy for the aggressiveness of prostate cancer.

The potential value of a blood- or urine-based test that could distinguish with accuracy between men with post-surgical Gleason scores of ? 6, 7, and ? 8 is potentially considerable. However, it would be unwise to think (based on the limited data available to date) that this protasome test is ?the answer.? A great deal more work will be needed before anyone could suggest with confidence that protasome levels in serum offered an accurate proxy for Gleason scores in a patient before he was even given a biopsy.

Source: http://prostatecancerinfolink.net/2011/05/12/protasomes-another-possible-marker-for-prostate-cancer-aggression/

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Powerful Parenting Knowledge - Teaching Little ones To Be Gender ...

arrowBuxZer ? Home-family ? Babies ? Powerful Parenting Knowledge - Teaching Little ones To Be Gender Delicate

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Self-discipline can't be done overnight, it is a procedure that have to be ongoing. It means that parents and guardians need to make compromises continually to be constant with the children's discipline. Particular values and family dynamic will need to also be taken into consideration. The troubles in Paul's situation are extremely apparent. Paul is the youngest of two boys and every is from a distinct marriage. Due to the fact she is absent from house most of the time, Paul's mother obtain it very difficult to shell out considerably time with her small children. To preserve Paul tranquil and preserve him from throwing tantrums, she generally gives in to his demands.

It is not also late to start disciplining your youngster. You and your companion will need to sit down and make a checklist of the spots in your child's lifestyle that will need to be addressed. What you do now will make a variation in the variety of human being your kid will turn into in the foreseeable future.

We don't consider it uncommon to see women enjoying with little one dolls and boys actively playing with toy army males. But we typically feel uneasy if we see them trade toys. Sometimes, we even react with shock and/or anger. In accordance to authorities, if youngsters are permitted to examine all that is probable, even taking away the gender bias, they will develop into effectively-rounded grown ups. So the thought of your small princess taking part in cowboys and Indians and your tiny guy enjoying household need to not be looked at as unnatural but alternatively and a implies of opening the doors of a fuller likely for them.

By the age of a single, youngsters have started to kind their very own gender identification idea, this kind of as a sensation of staying a girl or a boy. While some say the biology determines gender identification, the majority of psychologists are of the perception that it is established by the surroundings a little one lives in, this kind of as the way in which he or she is taken care of by parents, other family members and other children. After children establish gender identification, gender stability starts to take place. Throughout this time, little ones commence to establish gender-particular behaviors.

Children's formation of attitudes, actions and outlooks that are bias-cost-free count a lot on the favourable interactions with teachers and father and mother. For instance, cleaning their rooms and placing away their very own apparel need to be encouraged equally in equally women and boys. However it is usually a girl who does the cleansing doesn't necessarily mean that it is something only for adult females to do. It also aids if the father and mother trade chores from time to time. Mom can mow the lawn and rake leaves although dad does the laundry and cooks a handful of meals.

Expressing feelings is a thing that boys as perfectly as women need to be permitted to do. A lady really should have as a lot appropriate to exhibit assertiveness and vent annoyance as a boy ought to to break down and cry when he is upset. Compassion and nurturing really should be encouraged in boys and women ought to be instilled with courage and praise.

Initiating Discussions on Gender Challenges with Kids.

Why not treat your son or grandson to a nice new stylish outfit which will make them look really awesome and fashionable in front of their pals. Purchase them people trendy outfits they will just really like at www.boysclothingstore.co.uk

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Source: http://www.buxzer.com/home-family/babies/powerful-parenting-knowledge-teaching-little-ones-to-be-gender-delicate.html

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CANNES Q&A: 'Journals of Musan' Director Park Jung-bum

Chung Sung-Jun/Getty Images

Park Jung-bum

The Journals of Musan by Park Jung-bum paints a bleak portrait of a?North Korean?defector trying to find his niche in the South. The neo-realist drama takes what could have been humanist preaching into something far more noir and harrowing, as it sheds off layers of hypocrisy and divide that exist within a society and an individual. The writer-director-actor of the indie flick is a 35-year-old Park Jung-bum, who served as assistant director to the revered?Lee Chang-dong. The film debuted at the?Busan International Film Festival?last year, where it won the New Currents Award. It has since been hotwiring the festival circuit, picking up additional trophies at Rotterdam, Marrakesh, Deauville and Krakow, Poland. The Hollywood Reporter's Seoul correspondent Lee Hyo-won recently emailed Park, who was in?San Diego?after picking up Tribeca's Best?New Narrative?Director Award. The director spoke about his film, which recently released in local theaters, as well as lessons he learned from Lee Chang-dong.

The Hollywood Reporter: It must not have been easy -- writing, directing and playing the lead role in the film. What was most challenging about the project?

Park Jeong-bum: The biggest difficulty making the film was overcoming the lack of time and funds. Working with a small budget limited the amount of shooting time in a given location. Being penniless I had to cut scenes short and wasn't able to do many things the way I wanted to. I also feel indebted to the crew members, who had a difficult time since I was also acting on in the film.

THR: Your character is based on a real-life North Korean defector,?Jeon?Seung-cheol. How did you craft the screen persona, and what did you focus on while acting?

Park: I concentrated on realistically portraying my character to show why he lives the way he does. So I made an effort not to exaggerate and appear composed, to make even the most striking incidents appear like ordinary, everyday occurrences.

THR: South Korean directors have a unique position when it comes to telling stories about North Korea or North Korean refugees. But at the same time, it seems that the more personal a film is the more universal it is, rather than when it tries to preach social messages.

Park: My film began as a very personal story, something focusing on the day-to-day life of an individual. I think that's why audiences were able to empathize with the film more easily. Had I blatantly addressed the issue of North Korean defectors, it would have changed the story's turn of events and made things feel rather artificial. I think allowing the audience to view the North Korean defector as just an ordinary person made the story a bit more digestible, particularly since it shows social irony that an individual experiences. ? THR: Quite ironically, issues related to North Korean refugees remain largely taboo in South Korea, and are largely ignored unless they receive attention overseas.

Park: I think my film was overrated. I don't think it would have received so much attention without the North Korean defector factor, had it just been about a poor laborer. (Such films) receive the least bit of attention only if it gets favorable reviews overseas. It's because independent films get a limited release and lack funds for promotion.

THR: How do audiences react to your film? Were there any questions or comments that particularly struck you?

Park: In the credits I mention that the film is dedicated to the late Jeon Seung-cheol, and people were curious about how he actually died. Viewers asked if, as an extension of the film's plotline, Jeon was killed by friends or committed suicide. I began making the movie after my friend (Jeon) passed away from cancer, so I never really thought about that. But this is a very plausible question and really made an impression on me.

THR: What do you hope audiences take away from the film? ? Park: I hope watching the movie would inspire people to take a little more interest in the marginalized poor.

THR: How did working with director Lee Chang-dong influence your filmmaking?

Park: Director Lee Chang-dong has an imposing presence like mountains. He would throw questions for me to explore on my own, rather than directly provide answers or lessons. From this I was able to learn how to examine the way I view the world or the attitude with which I make films.

THR: What did Lee say about your work?

Park: He's a man of a few words. He said, 'Good work.'

THR: What do you have planned for your next film project?

Park: I'm working on the scenario for Sanda, (Living) which I plan to start shooting this winter. It's about a guy trying to save his suicidal older brother.

?

Source: http://feedproxy.google.com/~r/thr/international/~3/2_A4863cfO8/cannes-qa-journals-musan-director-188328

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'Jersey Shore' Girls -- Arrivederci, America!


Jwoww and Snooki just checked in at the Lufthansa ticket counter at Newark Airport -- destination:? Florence, Italy for "Jersey Shore" Season 4.

0512_jersey_shore_girls_airport_ex

They're at the business class desk right now, with a bunch of tacky, animal print luggage.

The guys, we're told, are on the way.051211_jerseyshore_video

Tags: Jwoww,?Snooki,?Jersey Shore


Source: http://www.tmz.com/2011/05/12/jersey-shore-snooki-jwoww-florence-italy-newark-airport-business-class-check-in/

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Optimize Your Operational Capability with CMMS Maintenance ...

Optimize Your Operational Capacity with CMMS Preservation Management Software program

Write-up by winstonjenkins

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Facility Management is one particular of the most essential features of any business. Managing a huge facility can be a daunting process. Facility Managers need to have to strike a balance among value and profit. CMMS Upkeep Management computer software is the ideal tool to automate your tracking method for optimizing operational ability and excellent maintenance.

CMMS Maintenance Management program helps to monitor and preserve the present and the budgeted expense for an organization?s machinery, human resources, stock and attributes. CMMS also ensures high quality control and liability reporting are in location in the course of manufacturing to stop needless losses or consumer dissatisfaction. Some of the features carried out by CMMS are scheduling tasks, reserving and distribution of supplies, recording expenditures and monitoring any strange incidents in the production approach. CMMS Servicing Management is an essential component of any plant or facility performance. Some of the most important CMMS Preservation Management computer software offers used are discussed beneath:

Inventory Control: This is a type of CMMS Upkeep Management software program used to handle spare components, instruments, allocating components and managing other components. Stock Control also offers with correct storage of all materials, buy order management, monitoring all delivery items and measuring actual stock stock.Safety Monitoring: This certain CMMS Upkeep Management software assists to track and monitor all the critical documentations along with regulations regarding basic safety. Security Monitoring CMMS Servicing Management computer software also aids in making certain proper safety of the tools and personnelAsset Management: This certain CMMS Upkeep Management computer software will help to file up-to-date information about all the actual attributes including gear. It assists to retain the warranties up to date, update the renewal dates of the service contracts, check the depreciation of spare elements and its acquire date. It also will help to assess the all round anticipated lifetime of all equipment so as to measure the genuine well worth of organization at a given position of time. Preventative Preservation: Periodic inspections of all tools and services are essential to lessen maintenance fees. This particular software program uses checklists for monitoring the upkeep progress and updates the worried department responsible.

CMMS Upkeep Management technique is an crucial instrument for liability defense. CMMS makes certain that a plant or a facility is getting audited to verify the basic safety techniques. A CMMS bundle should be obtained with much treatment after seeing its scalability and scope for future improvement and expansion. http://www.facilligence.com is a leader in CMMS Maintenance Management answers and Business Project Management Software which can be a reliable partner for your stock management.thirteen

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About the Author

Facilligence supplies end-to-conclude CMMS answers with thorough supporting providers.

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sales management
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Source: http://www.managersblog.net/optimize-your-operational-capability-with-cmms-maintenance-management-software-business-management/46917

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The Truth About Paid Surveys | Make Money

The Truth About Paid Surveys

Internet paid surveys can pay well if you can put aside the right amount of time just like a day job. This may sound confusing to you, because many people have said it is so easy to get paid to take surveys you can get hundreds of dollars a week by only doing one or two simple surveys. If Internet paid surveys paid so much the company would go bankrupt very easily. The truth is that making money with internet paid surveys can earn you a good income, but it will not replace a full time job if you are only doing a few internet paid surveys every week.

The reason why internet paid surveys are popular among income seekers is the freedom it offers. It is true that you have the flexibility to manage your time around surveys and still get paid for taking surveys. For homemakers or students who have free time between studies or household chores, this is a good opportunity to earn extra money. Students do not need to support their families and with a few hundred dollars per month they could spend purchase a new bike, or buy the latest equipment for a Playstation. Housewives who are paid for taking surveys can also use the cash to pay for groceries or other bills at home. In short, while internet paid surveys do let you get paid to take surveys, they are not really designed as full-time jobs. While this is true in general, there are still people who do attempt to make it a full time career, but you really must put in more time and effort.

Basically, the Internet paid surveys are online questionnaire surveys. They are used to indicate to the market research companies what you as a consumer thinks about a particular product so product companies can plan their product line and advertising campaigns. There may be millions of businesses that hire survey companies to conduct online surveys that pay you for the opinion that you have given them. Each survey is between 5 minutes to an hour to complete. Surveys Simple Pay $ 5 to $ 30, while a the more detailed ones pay more than $ 50. In general, the more expensive pay outs for internet paid surveys are for specialized people and require you to have specific knowledge in surveys such as medical research, that are directed towards more medical professionals.

Most survey companies would accept anyone regardless of age, sex, education or work. As long as you are consuming the product, you may qualify. But it helps if you are a professional or more experienced. Because the survey company?s profile you before you are invited to the Internet paid surveys, it is important that you list all of all the details and information about your background. This will significantly increase your chances of qualifying for more internet paid surveys and get paid to take surveys with them. You should also investigate wether the survey companies have a minimum age requirement.

Not all market research companies will pay cash to there members. Yes, you still will get paid for surveys in cash, but some companies prefer to reward their interviewers with prizes, gift certificates and the opportunity to enter their sweepstakes. different market research companies have different payment policies so be sure to consult with them. However, to quickly build your resume with companies while participating in a market study, do not be too picky about the type of paid internet survey you choose to complete. Think long term because some survey companies will invite you to even better paid surveys and participate in more internet paid surveys and that will help you establish a good track record.

Access useful advice about MLM secrets ? please study this site. The times have come when concise info is truly only one click away, use this opportunity.

Tags: surveys

Source: http://makemoney.myblogzone.info/2011/05/14/the-truth-about-paid-surveys/

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An Intro To Album Scrapbooking - Scrap N' Crafts

[unable to retrieve full-text content]No family members should be left out of having scrapbooks. It is great fun to record your furry (or feathery) child's life in a pet album. It's a unfortunate fact that our pets lives are all too brief, and what better way to treasure the memory of your ... Select Category, AnyThing, Arts, Arts and Crafts, Baking, Christmas, Collecting, Cooking, Family, Fun Stuff, Halloween, Hobbies, Holidays, Home and Garden, Humor, Parenting, Photography, Pregnancy and Family Planning ...

Source: http://scrapncrafts.com/blog/an-intro-to-album-scrapbooking/

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Home Staging College - Some Vital Issues That You Should Consider

If you are curious about developing a career as a home stager, home staging college is the first place to start. Home staging college is usually a blend of exterior and interior home decoration programs with a focus on the resale of homes. There?re many colleges that include tutorials in home staging, with more picking up program sets as this career choice becomes more accepted among males and females across the United States, Canada and the United Kingdom.

If you are interested in attending home staging college, there are a few points that it is advisable to take into account. Firstly, home staging college can be very expensive. You should decide if you are serious about home staging before you join. There are several techniques that you can go about this. The best is to locate a home staging business in your area, or an independent home staging professional, and ask for a little of their time. By doing so, you can ask them questions on the industry and learn if the tasks are what you would be interested in. Not like other occupations, home staging is sometimes done at the whim of the seller, who may have a job and will be unable to do tours of homes during normal business hours. Due to this, home staging professionals often have odd hours compared to those working nine to five shifts.

In addition to this, home staging college has many information that must be learned without some certifications granted. A home staging profession knows a little landscaping, a lot of internal design and is educated on the real estate market. But, with the exception of possibly internal design, most home staging colleges do not offer degrees aside from in home staging. Unless you join, you should discover exactly what degrees and certifications are offered by the college and learn if adding some extra courses could get you a 2nd degree in similar fields. If you are serious about establishing a home staging career, this can be exceptionally useful for you.

If you?ve experience as a home staging expert but don?t have certification, you can take a certification examination from a home staging college. It?s often considerably cheaper than taking full courses, as well as a lot less time intensive. However, if you?re not formally informed in home staging, acquiring a home staging certification without the coursework can cause you difficulties properly.

Source: http://www.arwst.com/finance/home-staging-college-some-vital-issues-that-you-should-consider/

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I want to start a consulting business to help small businesses cut ...

Use the people you have worked with in your previous jobs. If you have a 6 Sigma Master Black Belt you have been working for a while. Your collegues can be a big help in getting you into their companies. Relationships are everything in this business, especially since consultant are a dime a dozen! (I have a lot of experience in this area!) Be patient and good luck!

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Source: http://tuningmoney.com/i-want-to-start-a-consulting-business-to-help-small-businesses-cut-costs-how-do-i-get-customers/?utm_source=rss&utm_medium=rss&utm_campaign=i-want-to-start-a-consulting-business-to-help-small-businesses-cut-costs-how-do-i-get-customers

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